2024 Bub1b cancer

Bub1b cancer

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August undefined, 2024

WebLUAD is one of the most common causes of cancer death in men. BUB1B has been reported to contribute to the initiation and development of several cancers.In this paper, We found that BUB1B is up-regulated in LUAD and a biomarker for prognosis outcome by bioinformatic analysis. The same results appeared also in LUAD patients. WebApr 14, 2024 · A total of 8331 tumors and 24 cancer types from TCGA were included in the study. The cohort was divided into tumors harboring non-synonymous TP53 mutations in the coding sequence or at splice ...

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WebSep 25, 2024 · BUB1B was identified as an oncogene in prostate cancer through BUB1B-dependent regulation of MELK transcription. 26 In multiple myeloma (MM), BUB1B expression is closely associated with cell-division cycle protein 20 and cyclinB1/2 expression, resulting in the increased proliferation of MM cells, accounting for the … WebIt has been reported that low expression of BUB1B contributes to initiation and progression of human colon adenocarcinomas and lung cancer. 12,13 However, a large number of reports have demonstrated that overexpression of BUB1B is associated with progression and recurrence of bladder cancer, 14 gastric cancer, 15 esophageal squamous cell ... north carp

Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain …

WebApr 4, 2024 · BUB1B expression was highly correlated to CDC20 and CCNB1 expression in multiple myeloma cells, leading to increased cell proliferation.Bub1 expression promotes cell proliferation and leads to poor survival in multiple myeloma patients; BubR1 is a component of the Mitotic checkpoint complex and was reported to be overexpressed in Breast cancer. WebApr 3, 2024 · Cancer. In 2 of 19 colorectal cancer cell lines, Cahill et al. (1998) identified somatic mutations in the BUB1B gene. Neither mutation was found among 40 normal … http://www.cancerindex.org/geneweb/BUB1B.htm how to reset ipod touch password if forgotten

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701 - Gene ResultBUB1B BUB1 mitotic checkpoint serine

WebJul 1, 2008 · Mosaic variegated aneuploidy (MVA) is a rare autosomal recessive syndrome related to BUB1B gene mutations and characterized by multiple mosaic aneuploidies, cancer predisposition, and a distinct phenotype. We report on two mildly affected sibs with MVA syndrome but without BUB1B mutation. Both patie … north carolinians with tbiWebThe effects of the prognostic biomarker SAAL1 on cancer growth and its association with the immune microenvironment in lung adenocarcinoma. ... DLGAP5, CDCA2, CENPK, FAM111B, SPC24, DEPDC1B, CENPH, CDC25C, PARPBP, FANCI, SPC25, KIF18A, BUB1B, KIF20A, SGO2, and TTK in LAC tissues were obtained, and their relationship … north carpenters

"WebIn conclusion, at least one BUB1B mutation can result in autosomal recessively inherited susceptibility to gastrointestinal cancer, as do mutations in MUTYH and the mismatch-repair genes. " - Bub1b cancer

Bub1b cancer

Prevalence of germline mutations in the spindle assembly …

WebNevertheless, the precise biological role and underlying mechanisms of BUB1B in hepatocellular carcinoma (HCC) remain indistinct. Method: To figure out the role of … WebBUB1B - Explore an overview of BUB1B, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance …

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WebTo determine whether mutations in BUB1B are enriched in individuals with colorectal cancer (CRC), we performed amplicon-based targeted next-generation sequencing of BUB1B on germline DNA of 192 individuals with early-onset CRC (≤50 years). None of the individuals was found to be homozygous or compound heterozygous for mutations in … WebThe top 10 hub genes in the constructed PPI network were CDK1, CCNB1, TOP2A, AURKB, CCNA2, BUB1, AURKA, CDC20, MAD2L1, and BUB1B. The modules analysis …

WebFeb 21, 2024 · Cancer vaccines are emerging as a viable strategy for cancer treatment. In the current study, we screened for genes associated with the prognosis of patients with lung adenocarcinoma and positively correlated with antigen-presenting cell infiltration and identified KLRG1 and CBFA2T3 as potential tumor antigens for mRNA vaccines in lung … WebFeb 10, 2013 · First, in examining sister KT dynamics at metaphase, we showed that glioblastoma and other cancer cells sensitive to BUB1B inhibition have significantly …

WebIt has been reported that low expression of BUB1B contributes to initiation and progression of human colon adenocarcinomas and lung cancer. 12,13 However, a large number of … WebAug 16, 2016 · To determine the role of the N-terminal and internal Cdc20-binding domains in the protective effect of BubR1 overexpression on aneuploidy and cancer, we generated three distinct Flag-tagged mutant Bub1b transgenic mouse strains ().The first two mutants lacked either residues 1–363 containing the N-terminal Cdc20-binding domain (Bub1b …

WebBUB1B encodes a mitotic spindle check point (serine/threonine kinase B). ... Abnormal chromosome numbers, called “aneuploidy,” is a frequent feature of cancer cells. 6,206,242 In addition, many cancer cells also display chromosomal instability (CIN) or an aberrantly high change in the karyotype. CIN may lead to aneuploidy, but not all ...

WebJun 16, 2024 · BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) gene belongs to the spindle assembly checkpoint protein family, proven to be associated with many kinds of cancers. Protein kinases are crucial in metaphase to anaphase cellular transition. It is a primary element of spindle assembly checkpoint (SAC). This SAC is responsible for … north car parkWeb1 day ago · To sum up, our work sheds light on BUB1B's function in pan-cancer from various perspectives, including its pertinent signaling pathways, mutation locations, and connection to immune cell infiltration. BUB1B was shown to have a non-negligible role in pan-cancer, which is connected to immunology, cancer stemness, and genetic … north carpet abWebJan 11, 2024 · BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways Introduction. Cholangiocarcinoma (CCA), described as a malignancy … northcarpet.seWebSep 22, 2024 · Based on the fact that very little was found in the literature on the question of potential molecules and mechanism for high risk of cancer in patients with psoriasis, this … north car park gatwickWebThe BUB1B gene produces one such protein and p53 and RB, tumor suppressor proteins, also oversee this process. Metaphase to Anaphase Two important protein complexes … north carolinians definitionWebApr 12, 2024 · Cancer is the most deadly disease that causes death. Most likely, cancer is a problem in developed nations, with liver cancer coming in third in terms of mortality rates globally. ... antibiotic and amino acid biosynthesis, and HTLV-I infection for the KEGG pathway. KIF4A, BUB1B, FOXM1 CDC20, etc., were also identified as hub genes. … how to reset ipod touch 6th generationWebResearch suggests that impairment of the process that delays cell division until the correct time underlies the increased risk of cancer in MVA syndrome, although the mechanism is not completely understood. It is also unclear how BUB1B or TRIP13 gene mutations or aneuploidy is involved in the other features of the condition. how to reset ipod nano 2nd generation